Are you receiving a large number of "Delivery Error Report", about email messages that you did not send?
Or from email addresses referred to your domain, but which don't exist?

It is a technique called "spoofing", used by spammers, who send a huge volumes of email messages that appear to be from someone different than the actual source.
Spammers often use a random address in their spam list as the "from" address to disguise the true source.
These messages may be a huge number (hundreds or even thousands a day!)

It's nearly impossible to solve this issue (do you know a way to make impossible someone in the world send a letter, writing your name and address on the envelope as sender?), but there're some tips to make the job harder for spammers.

• set up an SPF record for your domain
  An SPF record will highly reduce the bouncebacks you get, because other mail providers will reject the spam messagee immediately, without ever sending a bounceback to the (spoofed) reply-to address.
  Not all mail providers check for it, so it's not 100% effective, but will be a great help.
• create a special email address, to be used around the web, in order to keep safe your real email address
• create a filter in your email client, in order to move this messages in a special directory, or to delete them
• don't make catch-all on your main email address: create a special email address for this purpouse
• never unsubscribe to spam email, never answr to spam email: this way, you make the spanner know that your email address ir real and used